super-resolution imaging

SRRF Imaging

One of the best parts of science is bringing new techniques and technologies into your lab. Our newest technique is SRRF imaging, which can more than double the resolution of nearly any widefield microscope, and can even be employed on living samples. The improvement this technology adds can be seen in the images of bovine …

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Cages – a New Plasma Membrane Structure

The Heit lab is excited to announce the discovery of membrane cages, a previously undescribed membrane structure. This discovery has been published in the journal Scientific Reports. Membrane cages act to transiently block the diffusion of membrane proteins, thus structuring proteins in cellular membranes over short periods of time. This discovery was made, with our collaborator Dr John de …

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New Paper Published!

The Heit lab, as part of a study led by Dr. Jane Rylett, has just published a paper on the cellular signalling involved in the cellular processes involved in Alzhimers disease.  This study utilized a novel method of measuring protein distributions in super-resolution images developed in our lab. Winick-Ng W, Caetano FA, Winick-Ng J, Morey TM, …

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Super-Resolution Imaging Paper Published

Today, PLoS Computational Biology has published our study, in which we developed a series of analytical routines for the analysis of molecular interactions in super-resolution microscopy images. These analyses include methods to quantify intermolecular interactions and the formation of larger molecular complexes. This was a large project, involving collaborations across multiple faculties at Western University. …

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