Super-Resolution Imaging Paper Published

PLoSCP2015Today, PLoS Computational Biology has published our study, in which we developed a series of analytical routines for the analysis of molecular interactions in super-resolution microscopy images. These analyses include methods to quantify intermolecular interactions and the formation of larger molecular complexes. This was a large project, involving collaborations across multiple faculties at Western University.

In addition to publishing these analytical methods, this study also includes a software package to perform the analyses described in the paper. This software – Molecular Interactions in Super-Resolution (MIiSR) is available for download from PLoS Computational Biology, with updated versions available here at

Caetano FA, Dirk BS, Tam JHK, Cavanagh PC, Goiko M, Ferguson SSG, Pasternak SH, Dikeakos JD, de Bruyn JR and Heit B. (2015) MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures. PLoS Comput Biol 11(12): e1004634. doi:10.1371/journal.pcbi.1004634