trafficking

Rab17 Mediated Antigen Sorting

We are excited to announce the publication of a follow-up paper to last-years study of Rab17 mediate sorting of antigens. In our first study we identified Rab17 as a protein which allowed macrophages to prevent generating immune responses after engulfing dead cells (a process termed efferocytosis), while still allowing macrophages to generate immune responses after engulfing pathogens. …

Rab17 Mediated Antigen Sorting Read More »

HIV Immunevasion

We are excited to announce the publication of a collaborative study, investigating one mechanism which is used by HIV to evade the immune system. This study, a product of our long-standing collaboration with Jimmy Dikeako’s lab at Western University, discovered that the HIV protein Nef sequesters a key component of the immune system (MHC I) inside the cell. MHC …

HIV Immunevasion Read More »