We, along with several of our collaborators, recently had a paper accepted for publication which will appear soon in the journal Molecular Biology of the Cell in the very near future. This study investigates the mechanisms by which the diffusion of Fractalkine (a protein which regulates inter-cellular communication) is controlled, and how this control over fractalkine diffusion is used to regulate its cleavage and release from a cell. This study provides mechanistic insights into how this protein functions both as a signal between neighbouring cells versus between distantly located cells.
Wong HS, Jaumouillé V, Heit B, Doodnauth SA, Patel S, Huang YW, Grinstein S, Robinson LA. Cytoskeletal confinement of CX3CL1 limits its susceptibility to proteolytic cleavage by ADAM10. Mol Biol Cell. 2014 Sep 24. pii: mbc.E13-11-0633. [Epub ahead of print] PubMed PMID: 25253723.
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