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Click Here for a complete listing of all pubmed-listed articles by Bryan Heit.

Peer-Reviewed Research Articles

Yin C, Vrieze AM, Rosoga M, Akingbasote J, Pawlak EN, Jacob RA, Hu J, Sharma N, Dikeakos JD, Barra L, Nagpal AD, Heit B. Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages. Front Immunol. 2020 Oct 23;11:594136. [Article] [Pubmed]

Tepperman A, Zheng DJ, Taka MA, Vrieze A, Le Lam A, Heit B. Customizable live-cell imaging chambers for multimodal and multiplex fluorescence microscopyBiochem Cell Biol. 2020 Oct;98(5):612-623. [Article] [Pubmed]

Crawford M, Liu N, Mahdipour E, Barr K, Heit B, Dagnino L. Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes. Mol Biol Cell. 2020 Apr 1;31(8):768-781. [Article] [Pubmed]

Caetano Crowley FA, Heit B, Ferguson SSG. Super-Resolution Imaging of G Protein-Coupled Receptors Using Ground State Depletion Microscopy. Methods Mol Biol. 2019;1947:323-336. [Article] [Pubmed]

Raheel H, Ghaffari S, Khosraviani N, Mintsopoulos V, Auyeung D, Wang C, Kim YH, Mullen B, Sung HK, Ho M, Fairn G, Neculai D, Febbraio M, Heit B, Lee WL. CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L740-L750. [Article] [Pubmed]

Blackburn JWD, Lau DHC, Liu EY, Ellins J, Vrieze AM, Pawlak EN, Dikeakos JD, Heit B. Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2. Eur J Immunol. 2019 Jan 18. [Article] [Pubmed]

Dirk BS, End C, Pawlak EN, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD. PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory  pathway. Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):519-525. [Article] [Pubmed]

Taruc K, Yin C, Wootton DG, Heit B. Quantification of Efferocytosis by Single-cell Fluorescence Microscopy. J Vis Exp. 2018 Aug 18;(138). [Article] [Pubmed]

Goiko M, de Bruyn JR, Heit B. Membrane Diffusion Occurs by Continuous-Time Random Walk Sustained by Vesicular Trafficking. Biophys J. 2018 Jun
19;114(12):2887-2899. [Article] [Pubmed]

Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME. Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes. Mol Biol Evol. 2018 Feb 1;35(2):440-450. [Article] [Pubmed]

Fung KY, Wang C, Nyegaard S, Heit B, Fairn GD, Lee WL. SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1. Front Physiol. 2017 Oct 30;8:841. [Article] [Pubmed]

Yin C, Argintaru D & Heit BRab17 mediates intermixing of phagocytosed apoptotic cells with recycling endosomes. Small GTPases. 2017. Eprint ahead of publication. [Article] [Pubmed]

Evans AL, Blackburn JW, Taruc K, Kipp A, Dirk BS, Hunt NR, Barr SD, Dikeakos JD, Heit B. Antagonistic Coevolution of MER Tyrosine Kinase Expression and FunctionMol Biol Evol. 2017 Mar 23. [Pubmed] [Article] [Free PDF]

Yin C, Kim Y, Argintaru D, Heit B. Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis. Cell Death and Disease. 2016 Dec 22;7(12):e2529. [PubMed][Article]

Dirk BS, Pawlak EN, Johnson AL, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD. HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling. Scientific Reports. 2016 Nov 14;6:37021. [Pubmed] [Article]

Evans AL, Blackburn JW, Yin C, Heit B. Quantitative Efferocytosis Assays. Methods Mol Biol. 2017;1519:25-41. [PubMed] [Article].

Goiko M, de Bruyn JR, Heit B. Short-Lived Cages Restrict Protein Diffusion in the Plasma Membrane. Scientific Reports. 2016 Oct 11;6:34987. [PubMed] [Article]

Winick-Ng W, Caetano FA, Winick-Ng J, Morey TM, Heit B, Rylett RJ. 82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions. Scientific Reports. 2016 Apr 7;6:23914. [PubMed] [Article]

Dunn HA, Chahal HS, Caetano FA, Holmes KD, Yuan GY, Parikh R, Heit B, Ferguson SS. PSD-95 regulates CRFR1 localization, trafficking and β-arrestin2 recruitmentCellular Signalling. 2016 May;28(5):531-40. [PubMed] [Aritcle]

Caetano FA, Dirk BS, Tam JH, Cavanagh PC, Goiko M, Ferguson SS, Pasternak SH, Dikeakos JD, de Bruyn JR, Heit B. MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures. PLoS Computational Biology. 2015 Dec 11;11(12):e1004634. [Pubmed] [Article]

Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Cardiovascular Research. 2015 Nov 1;108(2):268-77.  [Pubmed] [Article]

Flannagan RS, Heit B, Heinrichs DE. Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination. Cellular Microbiology. 2015 Sep 26. [Pubmed] [Article]

Hossain M, Qadri SM, Xu N, Su Y, Cayabyab FS, Heit B, Liu L. Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression. Journal of Immunology. 2015 Sep 1;195(5):2408-16. PMID: 26238489. [Pubmed] [Article]

Dirk BS, Heit B, Dikeakos JD. Visualizing Interactions Between HIV-1 Nef and Host Cellular Proteins Using Ground-State Depletion Microscopy. AIDS Research and Human Retroviruses. 2015 Jul;31(7):671-2. [Pubmed] [Article]

Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP, Heit B, Bilan PJ, Lee WL, Klip A. Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis. American Journal of Physiololgy – Endocrinology and Metabolism. 2015 Jul [Pubmed] [Article]

Azizi PM, Zyla RE, Guan S, Wang C, Liu J, Bolz SS, Heit B, Klip A, Lee WL. Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells. Molecular Biology of the Cell. 2015 Feb 15;26(4):740-50. [Pubmed] [Article]

Wong HS, Jaumouillé V, Heit B, Doodnauth SA, Patel S, Huang YW, Grinstein S, Robinson LA. Cytoskeletal confinement of CX3CL1 limits its susceptibility to proteolytic cleavage by ADAM10. Molecular Biology of the Cell. 2014 Dec 1;25(24):3884-99. [Pubmed] [Article]

Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.. Developmental Cell. 2013 Feb 25;24(4):372-83 [PubMed] [Article]

Heit B, Yeung T, Grinstein S. Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis. Am J Physiol Cell Physiol. 2011 Jan;300(1):C33-41. Epub 2010 Oct 6. [PubMed] [Article]

Yeung T, Heit B, Dubuisson JF, Fairn GD, Chiu B, Inman R, Kapus A, Swanson M, Grinstein S. Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturationJ Cell Biol. 2009 Jun  1;185(5):917-28. [PubMed] [PubMed Central] [Article]

Phillipson M, Heit B, Parsons SA, Petri B, Mullaly SC, Colarusso P, Gower RM, Neely G,  Simon SI, Kubes P. Vav1 is essential for mechanotactic crawling and migration ofneutrophils out of the inflamed microvasculatureJ Immunol. 2009 Jun 1;182(11):6870-8. [PubMed] [Article]

Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P. PTEN functions to ‘prioritize’ chemotactic cues and prevent ‘distraction’ in migrating neutrophilsNat Immunol. 2008 Jul;9(7):743-52. Epub 2008 Jun 8. [PubMed] [Article] [F1000]

Heit B, Liu L, Colarusso P, Puri KD, Kubes P. PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLPJ Cell Sci. 2008 Jan 15;121(Pt 2):205-14. [PubMed] [Article]

Phillipson M, Heit B, Colarusso P, Liu L, Ballantyne CM, Kubes P. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med. 2006 Nov 27;203(12):2569-75. Epub 2006 Nov 20. [PubMed] [PubMed Central] [Article] [F1000]

Heit B, Jones G, Knight D, Antony JM, Gill MJ, Brown C, Power C, Kubes P. HIV and other lentiviral infections cause defects in neutrophil chemotaxis, recruitment, and cell structure: immunorestorative effects of granulocyte-macrophage colony-stimulating factor. J Immunol. 2006 Nov 1;177(9):6405-14. [PubMed] [Article]

Heit B, Colarusso P, Kubes P. Fundamentally different roles for LFA-1, Mac-1 and alpha4-integrin in neutrophil chemotaxis. J Cell Sci. 2005 Nov 15;118 (Pt 22):5205-20. Epub 2005 Oct 25. [PubMed] [Article]

Khan AI, Heit B, Andonegui G, Colarusso P, Kubes P. Lipopolysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis. Microcirculation. 2005 Jul-Aug;12(5):421-32. [PubMed] [Article]

Khan AI, Kerfoot SM, Heit B, Liu L, Andonegui G, Ruffell B, Johnson P, Kubes P. Role of CD44 and hyaluronan in neutrophil recruitment. J Immunol. 2004 Dec 15;173(12):7594-601. [PubMed] [Article]

Kubes P, Heit B, van Marle G, Johnston JB, Knight D, Khan A, Power C. In vivo impairment of neutrophil recruitment during lentivirus infection. J Immunol. 2003 Nov 1;171(9):4801-8. [PubMed] [Article]

Heit B, Tavener S, Raharjo E, Kubes P. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol. 2002 Oct 14;159(1):91-102. Epub 2002 Oct 7. [PubMed] [PubMed Central] [Article] [F1000]

Reviews and Book Chapters

Taefehshokr N, Taefehshokr S, Hemmat N, Heit BCovid-19: Perspectives on Innate Immune EvasionFront Immunol. 2020 Sep 30;11:580641. [Article] [Pubmed]

Taefehshokr N, Yin C, Heit B. Rab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cells. Histol Histopathol2020 Sep 29:18252. [Article] [Pubmed]

Yin C, Heit B. Armed for destruction: formation, function and trafficking of neutrophil granules. Cell Tissue Res. 2018 Mar;371(3):455-471. Epub 2017 Nov 29. Review. [Article] [Pubmed]

Flannagan RS, Heit B, Heinrichs DE. Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus. Pathogens. 2015 Nov 27;4(4):826-68. Review. [Pubmed] [Article]

Wong CH, Heit B, Kubes P. Molecular regulators of leucocyte chemotaxis during inflammation. Cardiovasc Res. 2010 May 1;86(2):183-91. Epub 2010 Feb 2. Review. [PubMed] [Article]

Heit B and Kubes P. Bacterial products sabotage the innate immune system. Advan Sepsis. 2004 3(4):114–20. Review. [Article] [Journal]

Heit B, Kubes P. Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay. Sci STKE. 2003 Feb 18;2003(170):PL5. [PubMed] [Article]

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