The Heit lab, along with our collaborators in the Ferguson lab, have published a new study today in the journal Cell Signalling. This paper investigates the processes by which the internalization of a neurological receptor – CRFR1 – is regulated. This regulatory process may be important, and improper CRFR1 regulation is associated with some forms of metal illness.
Dunn HA, Chahal HS, Caetano FA, Holmes KD, Yuan GY, Parikh R, Heit B, Ferguson SS. PSD-95 regulates CRFR1 localization, trafficking and β-arrestin2 recruitment. Cell Signal. 2016 Feb 17. pii: S0898-6568(16)30038-9. [Epub ahead of print] PubMed PMID: 26898829.